Endocrine Abstracts

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of ob...

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

Introduction: Morbid obesity (MO) is associated with high frequency of type 2 diabetes mellitus (T2DM). Biliopancreatic diversion (BPD) is bariatric operation that results in rapid T2DM remission and increased GLP-1 levels. The aim of the study was to compare non-diabetic MO patients with normal weight controls and with patients who underwent BPD more than 2 years ago.Methods: Blood glucose levels, IRI, GLP-1, GIP and glucagon were measured during the or...

Introduction: Renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development of arterial hypertension (AH) in obese patient. Angiotensinogen expression in adipose tissue decreases during fasting and increases in case of overeating, that leads to changes in blood pressure (BP). The aim of the study was to assess the impact of obesity on the activity of RAAS and its role in the development of hypertension.Methods: 60 women, mean ag...

Introduction: Results obtained from PRIMAVERA study have demonstrated that 7.5% of obese individuals does not respond to sibutramine therapy. The aim of the study was to evaluate if GNB3, SERT, NET, TPH2 genes polymorphisms are associated with the results of obesity treatment with sibutramine.Methods: 69810 obese patients took sibutramine for at least 3 months. According to the results of 3 months therapy, we formed two groups of patients: 1) &#...

Introduction: Previous studies reported significant associations of steroid hormones with anthropometric parameters including body-mass-index (BMI) and waist circumference, as well as with some metabolic parameters such as triglycerides.Methods: 48 reproductive age males (age 18–49) were included in the study (27 obese individuals, 12 persons with excess body weight, 9 normal weight controls). We have examined the association between circulating st...

IntroductionProspective and retrospective trials report the incidence of endocrine adverse events provoked by immune checkpoint inhibitors (ICI) up to 30%. PD-1/PDL inhibitors have a higher incidence of thyroid dysfunction: hypothyroidism 5%-14%, transient hyperthyroidism – 3%-5%.The aim of the study was to assess thyroid function in PD-1/PDL treated patients.Materials and methods6...